Antigen-induced locomotor responses in lymphocytes.

Antigen-induced locomotor responses in lymphocytes

The effect of protein antigens on the locomotion of lymphocytes from the lymph nodes draining the site of antigenic challenge in immunized mice, and from the same nodes in control mice, was studied in filters using a checkerboard assay in which the absolute concentration and the concentration gradient of attractant was varied in a series of chambers. Serum albumin (HSA or BSA) was chemokinetic ...

Antigen-induced death of T-lymphocytes.

Resting mature T-lymphocytes are activated when they are triggered via their antigen-specific T-cell receptor (TCR) molecule or the associated CD3 antigen. In contrast, preactivated T-cells can undergo activation-induced cell death (AICD) in response to the same signals. Stimulation of activated T-cells upregulates the expression of the Fas-ligand, and the interaction of Fas-ligand with the cor...

Induced Th2 Responses to Soluble Protein Antigen

Synergistic Interaction of Macrophages and Lymphocytes in Antigen-induced Transformation of Lymphocytes

The role of macrophages and lymphocytes in antigen-induced transformation of lymphocytes has been investigated. Lymphocytes and macrophages were obtained from inbred strain 13 guinea pigs which were either unimmunized or immunized with complete Freund's adjuvant (CFA) or tetanus toxoid in CFA. The transformation response to PPD or tetanus toxoid was assayed by tritiated thymidine incorporation....

Induction of Chromosomal Damages in Lymphocytes Induced by Radiopaque Substances

The iodinated radiopaques are widely used in radiologicals procedures for their higher quality and for better pathological diagnosis. Since they are numerous and can lead to cellular toxicity and/or genotoxicity, this study was carried out to investigate the efficacy of two routine compounds, that is, urographin 76% and telbrix 38. For this purpose, the metaphasic chromosomes of 30 patients un...